Description

[Phenyl[(Trimethylsilyl)Amino]Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonate reagent, a key building block in advanced synthetic chemistry. Its value lies in its dual functionality, offering a protected amino group and a phosphonate moiety, which is crucial for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those containing phosphorus or requiring specific stereochemistry.
• Horner-Wadsworth-Emmons (HWE) Reaction Reagent: Used as a key component for the stereoselective formation of carbon-carbon double bonds (alkenes) in complex organic synthesis.
• Agrochemical Synthesis: Serves as a building block for creating advanced herbicides, insecticides, and plant growth regulators with enhanced efficacy.
• Ligand and Catalyst Development: Utilized in the preparation of novel phosphorus-containing ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptide Mimetics and Prodrug Design: The phosphonate group is valuable for creating bioisosteres and designing prodrugs with improved metabolic stability and bioavailability.
• Materials Science Research: Employed in the development of specialty polymers, surface modifiers, and flame retardants where phosphorus-silicon chemistry is advantageous.

Basic Information

Product Name	[Phenyl[(Trimethylsilyl)Amino]Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53044-42-1
Molecular Formula	C16H34NO3PSi3
Molecular Weight	403.68 g/mol
Synonyms	Bis(trimethylsilyl) [phenyl[(trimethylsilyl)amino]methyl]phosphonate; Phosphonic acid, P-[[(trimethylsilyl)amino]phenylmethyl]-, bis(trimethylsilyl) ester; (Aminomethyl)phosphonic Acid Tris(trimethylsilyl) Derivative; TMS-Protected Aminomethylphosphonate; Horner-Wadsworth-Emmons Reagent; Silylated Phosphonate Ester
EINECS	Contact for details

Quality Control

Every batch of [Phenyl[(Trimethylsilyl)Amino]Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical research and development. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition and maintain purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.