Description

[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Acetic Acid Trimethylsilyl Ester is a specialized organosilicon reagent featuring a protected phosphinylacetic acid moiety. This compound is valued for its role as a key synthetic intermediate and protecting group in advanced organic synthesis, particularly for phosphorus-containing molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing phosphonate or phosphate ester groups.
• Agrochemical Synthesis: Used in the research and development of new herbicides, insecticides, and plant growth regulators where phosphorus-based chemistry is essential.
• Peptide Mimetics & Prodrugs: Facilitates the introduction of phosphonate groups into peptide backbones or as a prodrug strategy to enhance bioavailability.
• Ligand & Catalyst Development: Acts as a precursor for phosphorus-containing ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Materials Science Precursor: Employed in the synthesis of specialty polymers, flame retardants, and surface-modifying agents.
• Chemical Research: A versatile reagent for method development in organic synthesis, enabling new routes to complex organophosphorus compounds.

Basic Information

Product Name	[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Acetic Acid Trimethylsilyl Ester
CAS No.	53044-27-2
Molecular Formula	C11H29O5PSi3
Molecular Weight	356.57 g/mol
Synonyms	Acetic acid, [bis[(trimethylsilyl)oxy]phosphinyl]-, trimethylsilyl ester; Trimethylsilyl [Bis(trimethylsiloxy)phosphinyl]acetate; Phosphonoacetic Acid Tris(trimethylsilyl) Ester; Tris(trimethylsilyl) Phosphonoacetate; (Trimethylsilyloxy)phosphinylacetic Acid Trimethylsilyl Ester; Acetic acid, phosphono-, tris(trimethylsilyl) ester; Tris-O-(trimethylsilyl) phosphonoacetate
EINECS	Contact for details

Quality Control

Our [Bis[(Trimethylsilyl)Oxy]Phosphinyl]Acetic Acid Trimethylsilyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to verify identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.