Description

[R,(-)]-2-Butanethiol CAS NO 52945-73-0 is a high-purity, chiral organosulfur compound characterized by its distinctive thiol functional group and specific optical rotation. This enantiomerically pure material is essential for applications requiring precise stereochemical control, such as in advanced pharmaceutical synthesis and the development of chiral ligands or catalysts. It serves as a critical building block for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to impart specific stereochemistry into their final products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological or metabolic pathways.
• Agrochemical Synthesis: Used in the research and production of enantiomerically pure pesticides and herbicides, where the specific stereoisomer can significantly impact biological activity and environmental safety.
• Chiral Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and catalysts used in asymmetric catalysis, enhancing the efficiency and selectivity of chemical transformations.
• Flavor & Fragrance Industry: Employed in the synthesis of specific sulfur-containing aroma compounds, contributing to the complex flavor profiles in food or fragrance formulations.
• Material Science Research: Investigated for use in creating functionalized polymers or self-assembled monolayers (SAMs) where surface properties are tuned by the thiol group.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for chromatography (GC, HPLC) and spectroscopy to ensure accurate identification and quantification in quality control laboratories.

Basic Information

Product Name	[R,(-)]-2-Butanethiol
CAS No.	52945-73-0
Molecular Formula	C4H10S
Molecular Weight	90.19 g/mol
Synonyms	(R)-(-)-2-Butanethiol; (R)-2-Butyl mercaptan; (R)-sec-Butyl mercaptan; (R)-1-Methyl-1-propanethiol; (2R)-2-Butanethiol; (R)-(-)-sec-Butyl mercaptan; Dextrorotatory 2-Butanethiol; (R)-Butane-2-thiol
EINECS	Contact for details

Quality Control

Our [R,(-)]-2-Butanethiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by GC or HPLC, to ensure it meets stringent specifications for enantiomeric excess (ee) and chemical purity. A Certificate of Analysis (COA) detailing specific results for identity, assay, optical rotation, and impurity profile is provided with every shipment, ensuring full traceability and compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials such as strong oxidizing agents. Due to its highly volatile nature, containers must be kept tightly sealed and upright to prevent leakage and evaporation. Recommended long-term storage temperature is 2-8°C (refrigerated) to maintain optimal stability and chiral integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Optical Rotation [α]	Contact for details
Specific Gravity (20°C)	0.83 - 0.85
Refractive Index (n20D)	1.435 - 1.445

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.