Description

Pentobarbital-D5 is a stable isotope-labeled analog of pentobarbital, where five hydrogen atoms are replaced by deuterium. This high-purity reference standard is essential for ensuring accuracy and reliability in quantitative analytical methods. It is primarily used by analytical laboratories, pharmaceutical researchers, and forensic toxicologists for applications requiring precise internal standardization.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS/MS and GC-MS analysis of pentobarbital in biological matrices.
• Pharmaceutical Research & Development: Used in pharmacokinetic, metabolic, and bioequivalence studies to track and quantify the parent drug.
• Forensic and Clinical Toxicology: Enables accurate measurement of pentobarbital concentrations in blood, urine, and tissue samples for diagnostic and legal purposes.
• Method Development and Validation: A key component in establishing and validating robust analytical protocols in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Manufacturing: Employed in the QC labs of pharmaceutical manufacturers to monitor product purity and consistency.
• Reference Material for Certified Standards: Used as a primary material to prepare and certify calibration standards and quality control samples.

Basic Information

Product Name	Pentobarbital-D5
CAS No.	52944-66-8
Molecular Formula	C11H13D5N2O3
Molecular Weight	235.29 g/mol
Synonyms	5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione-d5; Deuterated Pentobarbital; Pentobarbital (ethyl-D5); Nembutal-D5; 5-Ethyl-5-(1-methylbutyl)barbituric acid-d5; Pentobarbital-d5; Pentobarbital (D5)
EINECS	Contact for details

Quality Control

Our Pentobarbital-D5 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is fully characterized using advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.