Description

2,5-Piperazinedione,1,3,6-Trimethyl-,(3R,6R)-Rel-(9Ci) is a high-purity, stereochemically defined diketopiperazine derivative, a key structural motif in medicinal chemistry. This compound is valued for its role as a sophisticated chiral building block and scaffold in the research and development of novel pharmaceutical agents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery and advanced synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold for the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Peptidomimetics Research: Used as a constrained dipeptide surrogate to design and synthesize novel peptidomimetics with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry: Acts as a versatile building block for constructing diverse heterocyclic libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed as a chiral auxiliary or template in stereoselective synthesis to induce enantioselectivity in complex molecular constructions.
• Bioconjugation & Probe Development: Utilized in the development of chemical probes and bioconjugates for studying biological interactions and enzyme mechanisms.
• Fine Chemical Synthesis: Applied in the multi-step synthesis of specialty chemicals and advanced materials requiring specific stereochemistry.

Basic Information

Product Name	2,5-Piperazinedione,1,3,6-Trimethyl-,(3R,6R)-Rel-(9Ci)
CAS No.	52785-27-0
Molecular Formula	C7H12N2O2
Molecular Weight	156.18 g/mol
Synonyms	(3R,6R)-1,3,6-Trimethyl-2,5-piperazinedione; (3R,6R)-1,3,6-Trimethylpiperazine-2,5-dione; (3R,6R)-1,3,6-Trimethyl-2,5-diketopiperazine; Cyclo(L-alanyl-L-alanyl); (R,R)-1,3,6-Trimethyl-2,5-piperazinedione; (R,R)-1,3,6-Trimethyl-2,5-diketopiperazine; (R,R)-TMDKP; L-Alanyl-L-alanine anhydride
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,1,3,6-Trimethyl-,(3R,6R)-Rel-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.