Description

Hexaethylene Glycol Dichloride is a high-purity, functionalized polyethylene glycol derivative, serving as a versatile bifunctional linker and building block in advanced chemical synthesis. Its core value lies in its ability to introduce a defined hydrophilic spacer arm terminated with reactive chloride groups, enabling precise conjugation and modification of molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and specialty polymer industries, particularly for creating PEGylated drug conjugates, cross-linked hydrogels, and functionalized surfaces.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs requiring PEGylation to enhance solubility and circulation time.
• Bioconjugation & Linker Chemistry: Used to create cleavable or non-cleavable cross-linkers for attaching drugs, dyes, or targeting moieties to antibodies, proteins, and peptides.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for synthesizing degradable hydrogels, functional dendrimers, and smart polymeric materials.
• Surface Modification: Employed to functionalize nanoparticles, chromatography media, and biosensor surfaces with reactive groups for further coupling.
• Chemical Research & Development: A valuable reagent in organic synthesis for introducing polyether chains and facilitating nucleophilic substitution reactions.

Basic Information

Product Name	Hexaethylene Glycol Dichloride
CAS No.	52559-90-7
Molecular Formula	C12H24Cl2O5
Molecular Weight	319.22 g/mol
Synonyms	2,2'-(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(2-chloroethyl) ether; 1,11-Dichloro-3,6,9-trioxaundecane; PEG-6 dichloride; Hexaethylene glycol dichloride; Bis(2-chloroethoxy)polyethylene glycol; α,ω-Dichlorohexaethylene glycol; 3,6,9-Trioxaundecane-1,11-diyl dichloride
EINECS	Contact for details

Quality Control

Our Hexaethylene Glycol Dichloride is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.