Description

(5Alpha)-4,5-Epoxy-3,14-Dihydroxymorphinan-6-One Hydrochloride is a high-purity, semi-synthetic opioid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of potent analgesic agents and is essential for studying opioid receptor pharmacology. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of new therapeutic entities and controlled substance analysis.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent opioid analgesics and antagonists.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing of opioid-based medications.
• Pharmacological Research: Employed in in vitro and in vivo studies to investigate binding affinity, efficacy, and structure-activity relationships (SAR) at mu, delta, and kappa opioid receptors.
• Metabolite Studies: Serves as a precursor or standard for identifying and quantifying metabolic pathways of related opioid compounds.
• Process Chemistry: Utilized in scaling up synthetic routes and optimizing production processes for opioid active pharmaceutical ingredients (APIs).
• Forensic Analysis: Acts as an analytical standard in forensic toxicology for the identification and confirmation of specific opioid derivatives in biological samples.

Basic Information

Product Name	(5Alpha)-4,5-Epoxy-3,14-Dihydroxymorphinan-6-One Hydrochloride
CAS No.	52446-24-9
Molecular Formula	C₁₇H₁₉NO₄·HCl
Molecular Weight	337.80 g/mol (Free base: 301.34 g/mol)
Synonyms	14-Hydroxymorphinone Hydrochloride; Noroxymorphone Hydrochloride; 14-Hydroxynormorphinone HCl; 4,5α-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one Hydrochloride; (5α)-4,5-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one Hydrochloride; 6-Oxonoroxymorphone Hydrochloride; 14-Hydroxy-6-oxonormorphine Hydrochloride
EINECS	Contact for details

Quality Control

Our (5Alpha)-4,5-Epoxy-3,14-Dihydroxymorphinan-6-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and MS, and residual solvent analysis, to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.