Description

Karl Fischer Reagent CAS NO 52365-46-5 is a specialized chemical solution formulated for the precise volumetric determination of water content. This reagent is critical for ensuring product quality, stability, and compliance in industries where moisture control is paramount. It is an essential tool for quality control and research laboratories in the pharmaceutical, chemical, petrochemical, and food sectors.

Application

• Pharmaceutical Quality Control: Determination of water content in active pharmaceutical ingredients (APIs), excipients, and final drug products to ensure stability and meet pharmacopeial standards (e.g., USP, EP, JP).
• Chemical Industry Analysis: Accurate moisture assay in solvents, raw materials, intermediates, and specialty chemicals to verify purity and process control.
• Petrochemical and Fuel Testing: Measurement of trace water in hydrocarbons, oils, lubricants, and fuels to prevent corrosion and ensure performance specifications.
• Food and Beverage Analysis: Monitoring water activity and content in food ingredients, finished products, and packaging materials for shelf-life and safety.
• Polymer and Plastic Manufacturing: Controlling moisture levels in resins, polymers, and composites to prevent defects during processing.
• Environmental and Industrial Testing: Used in standard methods for determining water content in various solid and liquid samples.

Basic Information

Product Name	Karl Fischer Reagent
CAS No.	52365-46-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KFR; Karl Fischer Titrant; Volumetric Karl Fischer Reagent; Iodine/Sulfur Dioxide/Pyridine/Methanol Reagent; Water Determination Reagent; Hydranal®-Composite (generic reference); Coulometric Karl Fischer Reagent component; Methanolic Karl Fischer Solution
EINECS	Contact for details

Quality Control

Our Karl Fischer Reagent is manufactured under strict quality control protocols to ensure consistent titer, stability, and accuracy for reliable titration results. Each batch is tested to confirm performance against standardized water standards. Certificates of Analysis (COA) detailing assay, titer, and suitability for use are available upon request to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at room temperature (15-25°C). Due to its composition, this reagent is highly volatile and a strong oxidizer; keep away from heat, sparks, and incompatible materials. Ensure containers are securely sealed to prevent moisture ingress and evaporation.

Specification

Item	Specification
Appearance	Clear, brownish solution
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0%
Water Content (Karl Fischer)	< 0.1%
Titer (as H2O)	3.0 - 6.0 mg/mL (Standardized)
Suitability Test	Passes

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.