Description

n-(2-Sulfoethyl)Maleimide is a specialized, sulfonated maleimide derivative widely used as a key intermediate in advanced organic synthesis. Its unique bifunctional structure, featuring both a reactive maleimide group and a water-solubilizing sulfonate moiety, makes it invaluable for creating functionalized polymers and bioconjugates. This compound is essential for researchers and manufacturers in the pharmaceutical, polymer science, and bioconjugation reagent sectors seeking to introduce hydrophilic, anionic, or cross-linking properties into their molecules.

Application

• Bioconjugation & Protein Modification: A critical reagent for site-specific labeling of proteins, antibodies, and peptides via thiol-maleimide chemistry, enhancing solubility of the resulting conjugates.
• Functional Polymer Synthesis: Serves as a monomer or cross-linker for producing water-soluble, anionic, or stimuli-responsive polymers and hydrogels.
• Pharmaceutical Intermediates: Used in the synthesis of targeted drug delivery systems and prodrugs where enhanced aqueous solubility is required.
• Surface Modification & Coatings: Employed to functionalize surfaces (e.g., nanoparticles, chips) with hydrophilic, reactive layers for biosensor or diagnostic applications.
• Research & Development: A valuable building block in academic and industrial R&D for exploring novel polymer architectures and bio-organic hybrids.

Basic Information

Product Name	n-(2-Sulfoethyl)Maleimide
CAS No.	52338-78-0
Molecular Formula	C6H7NO5S
Molecular Weight	205.19 g/mol
Synonyms	2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethanesulfonic Acid; 1-(2-Sulfoethyl)-1H-pyrrole-2,5-dione; N-(2-Sulphoethyl)maleimide; Maleimide, N-(2-sulfoethyl)-; N-(2-Sulfoethyl)maleimide sodium salt (common salt form); SEM; 2-Maleimidoethanesulfonic Acid
EINECS	Contact for details

Quality Control

Our n-(2-Sulfoethyl)Maleimide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.