Description

1-Bromo-4,4-Dimethyl-2-Pentyne is a specialized halogenated alkyne building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a bromine atom and a terminal alkyne group, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as cross-coupling reactions and the synthesis of novel functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing alkyne functionalities for further derivatization via click chemistry.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its reactive handles allow for the creation of diverse chemical scaffolds.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of advanced polymers and functional materials with tailored properties.
• Organic Synthesis Reagent: Employed in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Useful for synthesizing novel ligands and organometallic complexes for catalytic applications.
• Life Sciences & Bioconjugation: The alkyne group enables its use in bioorthogonal chemistry for labeling biomolecules in proteomics and diagnostic research.

Basic Information

Item	Details
Product Name	1-Bromo-4,4-Dimethyl-2-Pentyne
CAS No.	52323-99-6
Molecular Formula	C7H11Br
Molecular Weight	175.07 g/mol
Synonyms	4,4-Dimethyl-1-bromo-2-pentyne; 1-Bromo-4,4-dimethylpentyne-2; 4,4-Dimethyl-2-pentyn-1-yl bromide; (4,4-Dimethylpent-2-yn-1-yl)bromide; Bromomethylneopentylacetylene; Neopentyl propargyl bromide
EINECS	Contact for details

Quality Control

Our 1-Bromo-4,4-Dimethyl-2-Pentyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistent performance. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.