Description

1-Acetyl-2,3-Dihydro-1H-Indole-5-Sulfonyl Chloride is a high-purity sulfonyl chloride derivative, a critical building block in advanced organic synthesis. Its primary value lies in its reactivity as a versatile electrophile for introducing the sulfonamide moiety, enabling the creation of complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of biologically active molecules, including potential kinase inhibitors, receptor antagonists, and other therapeutic agents.
• Agrochemical Research: Used to construct novel sulfonamide-based herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling proteins or modifying biomolecules to study function and interaction.
• Material Science: Building block for creating specialized polymers or functional materials with specific sulfonamide linkages.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects.

Basic Information

Product Name	1-Acetyl-2,3-Dihydro-1H-Indole-5-Sulfonyl Chloride
CAS No.	52206-05-0
Molecular Formula	C10H10ClNO3S
Molecular Weight	259.71 g/mol
Synonyms	5-(Chlorosulfonyl)-1-acetyl-2,3-dihydro-1H-indole; 1H-Indole-5-sulfonyl chloride, 1-acetyl-2,3-dihydro-; N-Acetyl-2,3-dihydroindole-5-sulfonyl chloride; 1-Acetyl-2,3-dihydroindole-5-sulfonyl chloride; 5-Acetamidoindoline sulfonyl chloride (related); Indoline-5-sulfonyl chloride, 1-acetyl derivative
EINECS	Contact for details

Quality Control

Our 1-Acetyl-2,3-Dihydro-1H-Indole-5-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC/GC data, confirming identity, purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.