Description

2-Phthalimidoethyl Phosphorodichloridate is a specialized organophosphorus compound primarily used as a key synthetic intermediate. Its value lies in its bifunctional reactivity, featuring both a phosphorodichloridate group and a protected amine (phthalimide), making it a versatile building block for complex molecule synthesis. This product is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleotide analogs, prodrugs, and other bioactive molecules with phosphate or phosphoramidate functionalities.
• Agrochemical Synthesis: Used in the production of advanced insecticides and herbicides that utilize organophosphate chemistry for enhanced efficacy.
• Peptide Mimetics & PROTACs: Serves as a linker or functional group in the design of peptide mimetics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Chemical Biology Probes: Employed in the development of activity-based probes and labeling reagents to study enzymatic processes, particularly those involving phosphatases and kinases.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialty polymers with unique degradation or adhesion properties.
• Ligand & Catalyst Development: Useful for synthesizing novel phosphorous-containing ligands for metal catalysis and asymmetric synthesis.

Basic Information

Product Name	2-Phthalimidoethyl Phosphorodichloridate
CAS No.	52198-45-5
Molecular Formula	C₁₀H₈Cl₂NO₄P
Molecular Weight	308.05 g/mol
Synonyms	Phosphorodichloridic Acid, 2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl Ester; N-(2-((Dichlorophosphinyl)oxy)ethyl)phthalimide; 2-Phthalimidoethyl Phosphorodichloridate; 2-(1,3-Dioxoisoindolin-2-yl)ethyl Phosphorodichloridate; 2-(Phthalimidoxy)ethyl Phosphorodichloridate; P,P-Dichloro-P-[2-(phthalimido)ethoxy]phosphine Oxide
EINECS	Contact for details

Quality Control

Every batch of 2-Phthalimidoethyl Phosphorodichloridate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) including purity (HPLC/NMR), identity confirmation, and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (Karl Fischer)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.