Description

4'-Nitrophenyl-2,3,4,6-Tetra-o-Acetyl-1-Thio-α-D-Mannopyranosid is a high-purity, protected thioglycoside building block essential for synthetic carbohydrate chemistry. This compound is a critical intermediate for the controlled synthesis of complex oligosaccharides and glycoconjugates, enabling precise glycosidic bond formation. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic tools, and biochemical probes.

Application

• Glycosylation Reagent: A key building block for the stereoselective synthesis of α-linked mannose-containing oligosaccharides and glycoconjugates.
• Pharmaceutical Intermediate: Used in the research and development of carbohydrate-based drugs, including antiviral agents, anti-inflammatory compounds, and vaccine adjuvants.
• Biochemical Probe Synthesis: Serves as a precursor for creating labeled (e.g., fluorescent, biotinylated) carbohydrate probes to study protein-carbohydrate interactions and cell surface recognition events.
• Glycopolymer and Material Science: Enables the creation of synthetic polymers with pendant sugar moieties for applications in biomaterials and targeted drug delivery systems.
• Enzyme Substrate/Inhibitor Development: Used to develop substrates or inhibitors for glycosidases and glycosyltransferases, important tools in enzymology and drug discovery.

Basic Information

Product Name	4'-Nitrophenyl-2,3,4,6-Tetra-o-Acetyl-1-Thio-α-D-Mannopyranosid
CAS No.	51885-01-9
Molecular Formula	C₂₂H₂₅NO₁₁S
Molecular Weight	511.50 g/mol
Synonyms	p-Nitrophenyl 2,3,4,6-Tetra-O-acetyl-1-thio-α-D-mannopyranoside; 1-Thio-α-D-mannopyranoside, 2,3,4,6-tetra-O-acetyl-, 4-nitrophenyl; α-D-Mannopyranoside, 2,3,4,6-tetra-O-acetyl-1-thio-, 4-nitrophenyl; 4-Nitrophenyl 1-thio-α-D-mannopyranoside tetraacetate; PNPTAM; 4-Nitrophenyl tetra-O-acetyl-1-thio-α-D-mannopyranoside
EINECS	Contact for details

Quality Control

Our 4'-Nitrophenyl-2,3,4,6-Tetra-o-Acetyl-1-Thio-α-D-Mannopyranosid is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.