Description

(20β)-16-[(1S)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl]-17-Norcorynan is a complex, high-purity alkaloid derivative with a defined stereochemistry, making it a valuable intermediate for advanced pharmaceutical research and development. This compound is critical for synthesizing novel therapeutic agents, particularly those targeting neurological pathways, due to its intricate fused ring system. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of central nervous system (CNS) drugs and other specialized bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new bioactive compounds within the corynan and yohimbane alkaloid families.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Investigated for its interaction with various neurotransmitter receptors and enzymes in preclinical studies.
• Process Chemistry Development: Used to develop and scale up efficient synthetic routes for complex natural product derivatives.

Basic Information

Product Name	(20β)-16-[(1S)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl]-17-Norcorynan
CAS No.	51820-25-8
Molecular Formula	C24H29N3
Molecular Weight	359.51 g/mol
Synonyms	17-Norcorynan-16-one, (20β)-16-[(1S)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-1-yl]-; 16-[(1S)-2,3,4,9-Tetrahydro-1H-β-carbolin-1-yl]-(20β)-17-norcorynan; (20β)-16-[(1S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indol-1-yl]-17-norcorynan; A complex yohimbane-type alkaloid derivative.
EINECS	Contact for details

Quality Control

We supply this advanced intermediate under strict quality assurance protocols to ensure batch-to-batch consistency and purity for critical research applications. Our production adheres to cGMP guidelines where applicable, and each batch is supported by a comprehensive Certificate of Analysis (COA). The COA includes data from advanced analytical techniques such as HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.