Description

D-[3-2H]Glucose CAS NO 51517-59-0 is a stable isotope-labeled analog of D-glucose, specifically deuterated at the 3-position. This compound is an essential tool for advanced metabolic research, enabling precise tracing and quantification of glucose utilization pathways in biological systems. It is primarily utilized by researchers and scientists in pharmaceutical development, biochemistry, and metabolic disease studies who require high-purity, isotopically labeled substrates for mass spectrometry (MS) and nuclear magnetic resonance (NMR) applications.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to map central carbon metabolism and quantify pathway activities in cells, tissues, or whole organisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS assays for the accurate quantification of glucose and its metabolites in biological matrices.
• Biochemical Research: Enables detailed studies on glycolysis, gluconeogenesis, and the pentose phosphate pathway in model systems.
• Diagnostic Development: Employed in the research and development of clinical assays for metabolic disorders like diabetes.
• Stable Isotope Labeling: Acts as a precursor for the synthesis of other deuterated compounds used in spectroscopic studies.

Basic Information

Product Name	D-[3-2H]Glucose
CAS No.	51517-59-0
Molecular Formula	C6H11DO6
Molecular Weight	181.16 g/mol
Synonyms	3-Deuterio-D-glucose; D-Glucose-3-d; Deuterated D-glucose; 3-Deutero-D-glucose; (3R)-3-Deuterio-D-glucose; 3-2H-Glucose; D-Glucose (3-2H); Stable Isotope-Labeled Glucose
EINECS	Contact for details

Quality Control

Our D-[3-2H]Glucose is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 2H), chemical purity, and specific optical rotation. We support research and development with materials that meet the stringent requirements for use as an analytical standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % 2H
Specific Optical Rotation	+52.5° to +53.0° (c=10 in H2O)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.