Description

Cholesterol-3-D1 is a high-purity, deuterium-labeled analog of cholesterol, specifically deuterated at the 3-position. This stable isotope-labeled compound is essential for advanced analytical and metabolic research, providing a critical internal standard for precise quantification. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers engaged in lipidomics, metabolic pathway tracing, and drug development studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical reference compound in LC-MS and GC-MS analyses for the accurate quantification of cholesterol and related sterols in biological samples.
• Metabolic Tracer Studies: Used in stable isotope labeling experiments to investigate cholesterol biosynthesis, absorption, and turnover rates in vivo and in vitro.
• Pharmaceutical Research: Employed in the development and validation of assays for lipid-lowering drugs and in studying drug-cholesterol interactions.
• Clinical Diagnostics: Acts as a calibrant or standard in advanced diagnostic kits for measuring cholesterol levels in serum or plasma with high specificity.
• Lipidomics and Biomarker Discovery: Facilitates the precise profiling of sterol metabolites in complex biological matrices for disease biomarker identification.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Useful as a probe in NMR studies due to the distinct signal of deuterium, aiding in structural and dynamic analyses.

Basic Information

Product Name	Cholesterol-3-D1
CAS No.	51467-57-3
Molecular Formula	C27H45DO
Molecular Weight	387.66 g/mol (approx.)
Synonyms	Cholesterol-d1 (3α-D); (3R)-Cholest-5-en-3-ol-d1; 3-Deuterocholesterol; Deuterated Cholesterol; 3-Deutero-5-cholesten-3β-ol; Cholesterol-3,4,13C3; Stable Isotope Labeled Cholesterol
EINECS	Contact for details

Quality Control

Our Cholesterol-3-D1 is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % D), chemical purity by HPLC, and identity confirmation. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % D)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.