Description

(20S)-17-Hydroxy-3α,20-Bis(Trimethylsiloxy)-5β-Pregnan-11-One is a high-purity, synthetic steroid derivative characterized by its specific stereochemistry and protective trimethylsilyl (TMS) ether groups. This compound serves as a critical advanced intermediate in the synthesis of complex steroid-based pharmaceuticals and fine chemicals, where precise molecular structure is paramount. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents and high-value specialty compounds.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid hormones and their analogs for therapeutic applications.
• Research & Development: Used in academic and industrial R&D settings for studying steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in process development and scale-up for the production of steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized as a tool compound in biochemical assays and enzymatic studies related to steroid pathways.
• Fine Chemical Synthesis: Acts as a precursor for the synthesis of other specialized, high-value steroid derivatives used in various research fields.

Basic Information

Product Name	(20S)-17-Hydroxy-3α,20-Bis(Trimethylsiloxy)-5β-Pregnan-11-One
CAS No.	51166-36-0
Molecular Formula	C₂₉H₅₄O₄Si₂
Molecular Weight	526.90 g/mol
Synonyms	17-Hydroxy-3α,20-bis(trimethylsiloxy)-5β-pregnan-11-one; 5β-Pregnan-11-one, 17-hydroxy-3α,20-bis(trimethylsiloxy)-, (20S)-; (20S)-17-Hydroxy-3α,20-bis[(trimethylsilyl)oxy]-5β-pregnan-11-one; 3α,20-Bis-O-(trimethylsilyl)-11-oxo-5β-pregnan-17-ol; 11-Oxo-5β-pregnane-3α,17,20-triol 3,20-bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our (20S)-17-Hydroxy-3α,20-Bis(Trimethylsiloxy)-5β-Pregnan-11-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and IR spectroscopy to ensure identity, purity, and conformity to specified standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.