Description

1H-Pyrazole-3,4,5-D3 is a deuterium-labeled derivative of the pyrazole heterocycle, a key structural motif in medicinal chemistry and agrochemical research. This isotopically labeled compound is specifically designed for use as an internal standard in quantitative mass spectrometry and as a tracer in metabolic and pharmacokinetic studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, agrochemical, and analytical chemistry industries who require high-purity, stable isotope-labeled compounds for advanced analytical applications.

Application

• Internal Standard for LC-MS/MS: Provides precise and accurate quantification of pyrazole-based active pharmaceutical ingredients (APIs) and their metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in drug discovery and development to study the absorption, distribution, metabolism, and excretion (ADME) profiles of novel compounds.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during API manufacturing.
• Agrochemical Research: Employed in environmental fate studies and residue analysis of pyrazole-class pesticides and herbicides.
• Chemical Reaction Mechanism Studies: Serves as a deuterium tracer to elucidate reaction pathways and kinetics in synthetic organic chemistry.
• NMR Spectroscopy Solvent: Can be used as a specialty solvent or shift reagent in nuclear magnetic resonance spectroscopy.

Basic Information

Product Name	1H-Pyrazole-3,4,5-D3
CAS No.	51038-79-0
Molecular Formula	C3H2D3N2
Molecular Weight	71.10 g/mol
Synonyms	Pyrazole-3,4,5-D3; 1H-Pyrazole-d3; 3,4,5-Trideuterio-1H-pyrazole; Deuterated Pyrazole; Pyrazole (3,4,5-d3); 1H-Pyrazole-3,4,5-d3; 1H-Pyrazole-d3 (3,4,5-D3); 1H-Pyrazole (3,4,5-D3)
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-3,4,5-D3 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by HPLC), isotopic enrichment (by 1H NMR and/or MS), and residual solvent content. We support compliance with cGMP and ISO 9001 standards for research and quality control applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.