Description

1-Trimethylsilyloxy-3-Trimethylsilylprop-2-Yne is a specialized organosilicon reagent featuring a silyl-protected propargylic alcohol moiety. This compound is a valuable synthetic building block, prized for its ability to introduce protected functional groups in complex organic synthesis. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing molecular frameworks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing alkyne or protected alcohol functionalities.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where its unique structure contributes to specific biological activity.
• Material Science: Serves as a precursor in the synthesis of silicon-containing polymers, dendrimers, and other advanced functional materials.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Nucleoside & Carbohydrate Chemistry: Employed in the modification and protection of sugar molecules and nucleoside analogs.
• Ligand & Catalyst Development: Useful for creating novel ligands and organometallic catalysts with tailored properties.

Basic Information

Product Name	1-Trimethylsilyloxy-3-Trimethylsilylprop-2-Yne
CAS No.	50965-66-7
Molecular Formula	C9H20OSi2
Molecular Weight	200.43 g/mol
Synonyms	3-(Trimethylsilyl)-2-propynyloxytrimethylsilane; 2-Propyn-1-ol, 3-(trimethylsilyl)-, 1-(trimethylsilyl) ether; 3-Trimethylsilyl-2-propynyloxytrimethylsilane; 1-(Trimethylsilyloxy)-3-(trimethylsilyl)-2-propyne; TMSOP; Bis(trimethylsilyl)propargyl ether; Propargyl alcohol, bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilyloxy-3-Trimethylsilylprop-2-Yne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.