Description

Dimethyl (3-Fluoro-2-Oxoheptyl)Phosphonate is a specialized organophosphorus compound, specifically a fluorinated phosphonate ester, that serves as a critical building block in advanced organic synthesis. Its primary value lies in its role as a key reagent for the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient and stereoselective construction of complex fluorinated olefins and enones. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who are developing novel active ingredients with enhanced properties through strategic fluorine incorporation.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used to construct fluorinated scaffolds for novel herbicides, fungicides, and insecticides, where fluorine atoms can improve metabolic stability, bioavailability, and binding affinity.
• Material Science Research: Employed in the development of fluorinated organic electronic materials, liquid crystals, and specialty polymers with tailored electronic and surface properties.
• Academic & R&D Laboratories: Serves as a versatile reagent for methodology development in organic chemistry, facilitating studies on new olefination protocols and fluorination strategies.
• Synthesis of Fluorinated Olefins: Specifically utilized in the HWE reaction to generate alpha,β-unsaturated ketones and esters containing a fluorine atom at a strategic position, which are difficult to access by other means.

Basic Information

Item	Details
Product Name	Dimethyl (3-Fluoro-2-Oxoheptyl)Phosphonate
CAS No.	50889-32-2
Molecular Formula	C9H18FO4P
Molecular Weight	240.21 g/mol
Synonyms	Dimethyl (3-Fluoro-2-oxoheptyl)phosphonate; (3-Fluoro-2-oxoheptyl)phosphonic acid dimethyl ester; Dimethyl 3-fluoro-2-oxoheptylphosphonate; Phosphonic acid, (3-fluoro-2-oxoheptyl)-, dimethyl ester; 3-Fluoro-2-oxoheptylphosphonic acid dimethyl ester; Fluorinated HWE Reagent; Fluorinated Phosphonate Ester
EINECS	Contact for details

Quality Control

Every batch of Dimethyl (3-Fluoro-2-Oxoheptyl)Phosphonate is manufactured and tested under a strict quality management system. We ensure high chemical purity and lot-to-lot consistency through advanced analytical techniques including NMR (¹H, ¹³C, ¹⁹F, ³¹P), GC-MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
¹⁹F NMR Purity	Conforms
³¹P NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.