Description

Ibudilast is a selective phosphodiesterase (PDE) inhibitor and macrophage migration inhibitory factor (MIF) inhibitor with significant anti-inflammatory and neuroprotective properties. This compound is of critical importance for pharmaceutical research and development, particularly in addressing complex neurological and inflammatory conditions. It is primarily needed by pharmaceutical manufacturers, biotechnology research firms, and academic institutions focused on developing treatments for multiple sclerosis, neuropathic pain, and other neurodegenerative diseases. Ibudilast CAS NO 50847-11-5 represents a high-value active pharmaceutical ingredient (API) for advanced therapeutic applications.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of neuroprotective and anti-inflammatory medications.
• Key intermediate in advanced pharmaceutical research for neurodegenerative diseases like multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS).
• Preclinical and clinical research compound for studying neuroinflammation, glial cell activation, and opioid withdrawal mitigation.
• Reference standard in analytical laboratories for quality control and method development using HPLC, LC-MS, or NMR.
• Building block for the synthesis of novel derivatives with enhanced pharmacological profiles.
• Component in cell culture studies investigating PDE and MIF pathway inhibition mechanisms.

Basic Information

Product Name	Ibudilast
CAS No.	50847-11-5
Molecular Formula	C₁₄H₁₈N₂O
Molecular Weight	230.31 g/mol
Synonyms	KC-404; AV-411; 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine; 2-Methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine (alternative tautomer representation); Ibudilastum; Ibudilast (USAN); MN-166
EINECS	Contact for details

Quality Control

Our Ibudilast is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. Certificates of Analysis (COA) detailing results from HPLC, NMR, and other relevant pharmacopeial methods are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.