Description

6-[(6R,7R)-6,7,8,9-Tetrahydro-6,8-Dimethyl-1,3-Dioxolo[4,5-H]Isoquinolin-7-Yl]-1,3-Benzodioxole-5-Acetic Acid is a high-purity, structurally complex organic compound that serves as a critical intermediate in advanced pharmaceutical synthesis. Its unique chiral tetrahydroisoquinoline-dioxole fused structure makes it a valuable building block for developing novel active pharmaceutical ingredients (APIs) with specific stereochemical requirements. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and other targeted therapies.
• Chemical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Asymmetric Synthesis: Employed in stereoselective synthesis due to its defined (6R,7R) configuration, enabling the construction of complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the design of novel bioactive molecules in academic and industrial R&D settings.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales for new APIs.

Basic Information

Product Name	6-[(6R,7R)-6,7,8,9-Tetrahydro-6,8-Dimethyl-1,3-Dioxolo[4,5-H]Isoquinolin-7-Yl]-1,3-Benzodioxole-5-Acetic Acid
CAS No.	50802-23-8
Molecular Formula	C22H23NO6
Molecular Weight	397.42 g/mol
Synonyms	1,3-Benzodioxole-5-acetic acid, 6-[(6R,7R)-6,7,8,9-tetrahydro-6,8-dimethyl-1,3-dioxolo[4,5-h]isoquinolin-7-yl]-; (6R,7R)-7-(1,3-Benzodioxol-5-yl)-6,8-dimethyl-6,7,8,9-tetrahydro-1,3-dioxolo[4,5-h]isoquinoline-5-carboxylic Acid (alternative IUPAC); Tetrahydroisoquinoline-dioxole acetic acid derivative; CAS 50802-23-8; 6-[(6R,7R)-6,7,8,9-Tetrahydro-6,8-dimethyl-1,3-dioxolo[4,5-h]isoquinolin-7-yl]-1,3-benzodioxole-5-acetic acid
EINECS	Contact for details

Quality Control

Our 6-[(6R,7R)-6,7,8,9-Tetrahydro-6,8-Dimethyl-1,3-Dioxolo[4,5-H]Isoquinolin-7-Yl]-1,3-Benzodioxole-5-Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (6R,7R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.