Description

5-[(Trimethylsilyl)]-1-Methylimidazole is a versatile organosilicon-protected imidazole derivative, serving as a crucial building block and protective reagent in advanced organic synthesis. Its primary value lies in its ability to act as a silylating agent and a masked nucleophile, facilitating complex transformations under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those containing imidazole or purine scaffolds.
• Silylating Agent: Used to introduce the trimethylsilyl (TMS) protecting group onto hydroxyl, amino, or other sensitive functional groups during multi-step synthesis.
• Catalyst/Ligand Precursor: Serves as a precursor for N-heterocyclic carbene (NHC) ligands and other organocatalysts used in metal-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Employed in the manufacture of advanced pesticides and herbicides that require specific heterocyclic structures.
• Material Science: Used in the research and development of silicon-based polymers, resins, and advanced functional materials.
• Chemical Research: A valuable reagent for academic and industrial R&D in methodologies involving nucleophile protection and deprotection strategies.

Basic Information

Item	Details
Product Name	5-[(Trimethylsilyl)]-1-Methylimidazole
CAS No.	50694-57-0
Molecular Formula	C7H14N2Si
Molecular Weight	154.29 g/mol
Synonyms	1-Methyl-5-(trimethylsilyl)imidazole; 5-(Trimethylsilyl)-1-methyl-1H-imidazole; 1-Methyl-5-trimethylsilylimidazole; N-Methyl-5-trimethylsilylimidazole; TMS-Methylimidazole; 5-TMS-1-Methylimidazole; 1-Methylimidazole-5-trimethylsilane
EINECS	Contact for details

Quality Control

Our 5-[(Trimethylsilyl)]-1-Methylimidazole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.