Description

n-Acetyl 6-Chlorotryptophan is a chemically modified derivative of the essential amino acid tryptophan, featuring both acetylation and chlorination at the 6-position of the indole ring. This specific functionalization makes it a valuable advanced pharmaceutical intermediate and a crucial building block for medicinal chemistry research. It is primarily utilized by research institutions and pharmaceutical developers focused on synthesizing novel bioactive compounds and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Peptide Synthesis: Used as a protected or modified amino acid residue in solid-phase and solution-phase peptide synthesis to introduce specific chlorinated indole motifs.
• Biochemical Research: Serves as a standard or reference compound in analytical studies of tryptophan metabolism and enzyme inhibition assays.
• Medicinal Chemistry: Employed to explore structure-activity relationships (SAR) by studying the effects of halogenation and acetylation on biological activity.
• Proteomics & Labeling: Potential use in chemical proteomics as a probe or tag due to its unique chemical handle for further conjugation.

Basic Information

Item	Detail
Product Name	n-Acetyl 6-Chlorotryptophan
CAS No.	50517-10-7
Molecular Formula	C13H13ClN2O3
Molecular Weight	280.71 g/mol
Synonyms	6-Chloro-N-acetyltryptophan; N-Acetyl-6-chloro-L-tryptophan; N-Acetyl-6-chlorotryptophan; 2-Acetamido-3-(6-chloro-1H-indol-3-yl)propanoic acid; (2S)-2-Acetamido-3-(6-chloro-1H-indol-3-yl)propanoic acid; 6-Chlorotryptophan N-acetyl derivative; Ac-6-Cl-Trp-OH
EINECS	Contact for details

Quality Control

Our n-Acetyl 6-Chlorotryptophan is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.