Description

3-(o-Chlorobenzoyl)-5-Ethyl-2-(Iodoacetylamino)Thiophene is a high-value, multi-functional heterocyclic building block and advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of complex molecules, particularly in medicinal chemistry where its unique thiophene core and reactive iodoacetyl group enable targeted derivatization. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of novel therapeutic agents, particularly those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Serves as a building block for creating new crop protection agents and pesticides with enhanced efficacy.
• Bioconjugation & Probe Development: The reactive iodoacetyl group allows for selective conjugation to thiol groups in proteins, peptides, or other biomolecules for creating probes or antibody-drug conjugates (ADCs).
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for exploratory chemical synthesis and methodological studies.

Basic Information

Product Name	3-(o-Chlorobenzoyl)-5-Ethyl-2-(Iodoacetylamino)Thiophene
CAS No.	50509-01-8
Molecular Formula	C15H13ClINO2S
Molecular Weight	433.69 g/mol
Synonyms	2-[(Iodoacetyl)amino]-5-ethyl-3-(2-chlorobenzoyl)thiophene; 5-Ethyl-2-(iodoacetamido)-3-(2-chlorobenzoyl)thiophene; 3-(2-Chlorobenzoyl)-5-ethyl-2-(iodoacetamido)thiophene; 2-(Iodoacetamido)-5-ethyl-3-(o-chlorobenzoyl)thiophene; Thiophene derivative CAS 50509-01-8; Iodoacetylaminothiophene derivative; o-Chlorobenzoyl thiophene intermediate
EINECS	Contact for details

Quality Control

Our 3-(o-Chlorobenzoyl)-5-Ethyl-2-(Iodoacetylamino)Thiophene is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your research and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.