Description

(-)-Grahamimycin A CAS NO 50376-39-1 is a specific enantiomer of the grahamimycin A macrolide antibiotic, a compound of significant interest in advanced research and development. This chiral molecule is valued for its distinct biological activity profile, which is critical for studying structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on antimicrobial discovery and chemical biology.

Application

• Pharmaceutical Research & Development: Serves as a key chiral intermediate or reference standard in the discovery and synthesis of novel antibiotic candidates.
• Chemical Biology Studies: Used as a molecular probe to investigate bacterial mechanisms of action and resistance pathways.
• Analytical Reference Standard: Employed in HPLC, LC-MS, and NMR for method development, validation, and quality control of related compounds.
• Academic Research: Fundamental studies in organic synthesis, medicinal chemistry, and microbiology to explore new macrolide derivatives.
• Biocatalysis & Enzymology: Investigation of enzymatic reactions and chiral specificity due to its defined stereochemistry.

Basic Information

Product Name	(-)-Grahamimycin A
CAS No.	50376-39-1
Molecular Formula	C34H54O9
Molecular Weight	606.79 g/mol
Synonyms	(-)-Grahamimycin A1; Grahamimycin A, (-)-form; (3R,5R,8R,9S,10S,13R,14S,17R)-17-((2S,4R,5S,6S)-5,6-Dihydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,10,13-triol; Antibiotic LL-D05139β; LL-D05139β
EINECS	Contact for details

Quality Control

Our (-)-Grahamimycin A is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.