Description

Pentamidine-D4 2Hcl is a deuterated isotopologue of the antiprotozoal agent Pentamidine, where four hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical methods. It is a critical material for pharmaceutical research, clinical laboratories, and contract research organizations (CROs) engaged in drug metabolism, pharmacokinetic (DMPK) studies, and therapeutic drug monitoring.

Application

• LC-MS/MS Internal Standard: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of Pentamidine.
• Pharmacokinetic & Bioanalytical Studies: Enables precise measurement of drug concentration in biological matrices (plasma, serum, tissue) during DMPK research.
• Clinical Research & Diagnostics: Supports method development and validation for therapeutic drug monitoring in patients undergoing treatment.
• Metabolite Identification & Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in metabolism studies.
• Pharmaceutical Quality Control: Used in impurity profiling and assay development for drug substance and product analysis.
• Regulatory Submissions: Provides essential data traceability and method validation support for FDA, EMA, and other regulatory agency filings.

Basic Information

Product Name	Pentamidine-D4 2Hcl
CAS No.	50357-45-4
Molecular Formula	C19H20D4N4O2·2HCl
Molecular Weight	~ 594.5 g/mol
Synonyms	1,5-Bis(4-amidinophenoxy)pentane-d4 Dihydrochloride; 4,4'-[Pentane-1,5-diylbis(oxy)]dibenzamidine-d4 Dihydrochloride; Pentamidine-d4 Dihydrochloride; Deuterated Pentamidine 2HCl; [²H₄]-Pentamidine 2HCl; Pentamidine (phenyl-d4) Dihydrochloride; Internal Standard for Pentamidine
EINECS	Contact for details

Quality Control

Our Pentamidine-D4 2Hcl is manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is subjected to rigorous testing, including NMR and Mass Spectrometry for isotopic enrichment verification, and HPLC for chemical purity assessment. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (e.g., ≥98 atom % D), chemical purity (e.g., ≥95%), and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity	≥98 atom % D
Chemical Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.