Description

(+)-4-Amino-α-[(tert-Butylamino)Methyl]-3,5-Dichlorobenzyl Alcohol Hydrochloride is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a critical building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting adrenergic receptors. Industrial and research organizations engaged in the synthesis of complex drug molecules, especially within the cardiovascular and respiratory therapeutic areas, require this material for its specific stereochemistry and functional groups. We supply this intermediate with a focus on consistent quality and reliable global supply chains to support critical R&D and manufacturing processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Adrenergic Receptor Agonist Research: Used in the development and production of compounds targeting β-2 adrenergic receptors.
• Bronchodilator Precursor: Serves as a critical precursor in the manufacture of certain bronchodilator medications.
• Cardiovascular Drug Synthesis: Employed in research and production pathways for cardiovascular therapeutics.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions due to its defined chiral center.
• Process Chemistry & Scale-Up: Supports process development, optimization, and commercial-scale manufacturing of specialty pharmaceuticals.
• Reference Standard: Can be used as an analytical standard for quality control and regulatory submissions.
• Custom Synthesis Building Block: Provides a versatile starting point for medicinal chemistry and custom synthesis projects.

Basic Information

Item	Details
Product Name	(+)-4-Amino-α-[(tert-Butylamino)Methyl]-3,5-Dichlorobenzyl Alcohol Hydrochloride
CAS No.	50310-83-3
Molecular Formula	C13H21Cl2N2O • HCl
Molecular Weight	341.69 g/mol
Synonyms	(R)-4-Amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol hydrochloride; (R)-Clenbuterol impurity; (R)-Clenbuterol related compound; 1-(4-Amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol hydrochloride (enantiomer); (+)-Clenbuterol impurity; (R)-N-tert-Butyl-1-(4-amino-3,5-dichlorophenyl)-2-aminoethanol hydrochloride; 4-Amino-α-[(1,1-dimethylethyl)amino]methyl]-3,5-dichloro-benzenemethanol hydrochloride; (R)-Clenbuterol HCl intermediate
EINECS	Contact for details

Quality Control

Our (+)-4-Amino-α-[(tert-Butylamino)Methyl]-3,5-Dichlorobenzyl Alcohol Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.