Description

(-)-4-Amino-α-[(tert-Butylamino)Methyl]-3,5-Dichlorobenzyl Alcohol is a chiral, substituted benzyl alcohol derivative with significant pharmacological interest. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) in the development of specialized therapeutics. It is primarily needed by research institutions and pharmaceutical manufacturers focused on adrenergic receptor-targeting drugs, central nervous system (CNS) agents, and cardiovascular medications.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug molecules, particularly β-adrenergic receptor agonists and antagonists.
• Biochemical Research: Used as a reference standard or tool compound in pharmacological studies investigating adrenergic pathways.
• Asymmetric Synthesis: Its chiral structure makes it valuable for developing enantioselective synthetic routes and studying stereochemical effects in drug action.
• Preclinical Development: Employed in the discovery and optimization phases of new chemical entities (NCEs) targeting respiratory or cardiovascular conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	(-)-4-Amino-α-[(tert-Butylamino)Methyl]-3,5-Dichlorobenzyl Alcohol
CAS No.	50306-03-1
Molecular Formula	C13H20Cl2N2O
Molecular Weight	291.22 g/mol
Synonyms	(-)-4-Amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl Alcohol; (R)-4-Amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl Alcohol; 3,5-Dichloro-4-amino-α-[(tert-butylamino)methyl]benzyl Alcohol; 50306-03-1; Salmeterol Intermediate; Salmeterol Related Compound; Adrenergic β-2 Agonist Intermediate; Benzyl Alcohol, 4-amino-α-[(1,1-dimethylethylamino)methyl]-3,5-dichloro-, (αR)-
EINECS	Contact for details

Quality Control

Our (-)-4-Amino-α-[(tert-Butylamino)Methyl]-3,5-Dichlorobenzyl Alcohol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.