Description

1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid Hydrochloride is a versatile and high-purity organic building block, crucial for advanced chemical synthesis. Its primary value lies in serving as a key chiral intermediate for the development of complex pharmaceutical compounds and fine chemicals. This product is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for API development and process chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Organic Synthesis Reagent: Used in the construction of complex heterocyclic compounds and natural product analogs due to its fused isoquinoline structure.
• Agrochemical Research: Serves as a precursor in the development of novel pesticides and herbicides with specific biological activity.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in stereoselective synthesis to control the three-dimensional structure of target molecules.
• Biochemical Research: Used in the study of enzyme inhibitors and receptor ligands, contributing to medicinal chemistry and drug discovery programs.
• Fine Chemical Production: Integral to the manufacture of dyes, pigments, and other high-value specialty chemicals requiring precise molecular architecture.

Basic Information

Product Name	1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid Hydrochloride
CAS No.	5926-71-6
Molecular Formula	C10H11NO2·HCl
Molecular Weight	213.66 g/mol
Synonyms	1,2,3,4-Tetrahydro-1-isoquinolinecarboxylic Acid Hydrochloride; THIQ-1-COOH·HCl; (1S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic Acid Hydrochloride (for chiral form); 1-Carboxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride; 1,2,3,4-Tetrahydro-2-isoquinolinecarboxylic Acid Hydrochloride (tautomer); Isoquinoline-1-carboxylic Acid, 1,2,3,4-tetrahydro-, Hydrochloride; 1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid HCl Salt
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity (where applicable), to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.