Description

Bis(Trimethylsilyl)Chloromethane is a versatile organosilicon reagent featuring a chloromethylene group flanked by two trimethylsilyl moieties. This compound is highly valued for its role as a key synthon in organic synthesis, particularly for introducing functionalized methylene units and protecting groups. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and efficient synthetic pathways.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in constructing complex molecular frameworks.
• Peterson Olefination Reagent: Used in the Peterson olefination reaction to generate alkenes from carbonyl compounds, a fundamental transformation in fine chemical synthesis.
• Nucleophilic Chloromethylation Agent: Serves as a source of the chloromethyl anion equivalent for nucleophilic addition reactions with various electrophiles.
• Silyl Enol Ether Precursor: Employed in the preparation of silyl enol ethers, which are pivotal intermediates for regioselective aldol and alkylation reactions.
• Polymer & Material Science: Used in the modification of polymers and the synthesis of specialized silicone-based materials and coatings.
• Agrochemical Synthesis: Acts as an intermediate in the production of certain herbicides, fungicides, and other crop protection agents.
• Laboratory Research: A valuable reagent for methodological development and exploratory chemistry in academic and industrial R&D settings.

Basic Information

Product Name	Bis(Trimethylsilyl)Chloromethane
CAS No.	5926-35-2
Molecular Formula	C7H19ClSi2
Molecular Weight	194.86 g/mol
Synonyms	Chloro[bis(trimethylsilyl)]methane; (Chloromethylene)bis(trimethylsilane); Trimethyl[chloro(trimethylsilyl)methyl]silane; BTSCM; NSC 163082; Chloromethylene Bis(trimethylsilane); α-Chloro-α-(trimethylsilyl)trimethylsilylmethane
EINECS	227-666-6

Quality Control

Our Bis(Trimethylsilyl)Chloromethane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required for pharmaceutical intermediates and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.