Description

Codeine Phosphate Sesquihydrate is a high-purity pharmaceutical active ingredient (API) derived from morphine, primarily used for its potent analgesic and antitussive (cough-suppressant) properties. Its value lies in providing a controlled, effective therapeutic effect for moderate pain and persistent coughs, making it a critical component in numerous prescription and over-the-counter formulations. This compound is essential for manufacturers in the pharmaceutical industry, particularly those producing pain management syrups, tablets, and combination cold/flu medications.

Application

• Pharmaceutical Analgesic: A key active ingredient in prescription and OTC medications for the relief of mild to moderate pain.
• Antitussive Formulations: Widely used in cough syrups and lozenges to suppress the cough reflex effectively.
• Combination Cold & Flu Medications: Incorporated into multi-symptom relief products alongside antihistamines, decongestants, and expectorants.
• Hospital & Clinical Use: Employed in controlled settings for post-operative pain management and palliative care.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical testing in pharmaceutical laboratories.
• Research & Development: Used in biochemical research to study opioid receptors and develop new analgesic compounds.

Basic Information

Product Name	Codeine Phosphate Sesquihydrate
CAS No.	5913-76-8
Molecular Formula	C₁₈H₂₁NO₃ · H₃PO₄ · 1½H₂O
Molecular Weight	424.37 g/mol (anhydrous basis)
Synonyms	Codeine Phosphate Hemihydrate; Morphine-3-methyl ether phosphate; 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate; Methylmorphine phosphate; Codicept; Paveral; 3-Methylmorphine phosphate sesquihydrate
EINECS	227-671-2

Quality Control

Our Codeine Phosphate Sesquihydrate is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure compliance with major pharmacopoeial standards such as USP, EP, and BP. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring it meets the stringent requirements for pharmaceutical ingredient use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (Phosphate)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	5.0% - 7.5%
Specific Rotation	-98° to -102° (c = 2 in water)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.