Description

Codeine Nitrate is the nitrate salt form of the well-known opioid alkaloid codeine, a key pharmaceutical intermediate. This compound is essential for its role in the synthesis of controlled analgesic and antitussive medications, offering a critical building block for pharmaceutical manufacturing. It is primarily utilized by fine chemical producers, research institutions, and pharmaceutical companies engaged in the development and production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as a precursor in the synthesis of codeine-based analgesic and antitussive APIs.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Research & Development: Used in pharmacological and biochemical research to study opioid receptor interactions and metabolic pathways.
• Controlled Substance Synthesis: A regulated starting material for the manufacture of other opioid derivatives under strict compliance protocols.
• Chemical Synthesis: Employed in organic synthesis for introducing the codeine structure into more complex molecules.

Basic Information

Product Name	Codeine Nitrate
CAS No.	5913-75-7
Molecular Formula	C18H21NO3 • HNO3
Molecular Weight	376.38 g/mol
Synonyms	Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5α,6α)-, nitrate (salt); Codeine mononitrate; 3-Methylmorphine nitrate; Methylmorphine nitrate
EINECS	227-671-2

Quality Control

Our Codeine Nitrate is produced under strict quality management systems to ensure batch-to-batch consistency and reliability. We offer material suitable for pharmaceutical applications, with testing aligned to common pharmacopeial standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.