Description

[R,(-)]-2-Bromobutane is a high-purity chiral alkyl halide, a crucial building block in asymmetric synthesis and pharmaceutical research. Its defined stereochemistry enables the precise construction of complex molecules, ensuring high enantiomeric purity in final products. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality chiral intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals requiring specific stereochemistry.
• Asymmetric Synthesis: Used in nucleophilic substitution reactions (SN2) to introduce chiral butyl groups with inversion of configuration.
• Agrochemical Research: Serves as a precursor in developing chiral pesticides and herbicides where biological activity is stereospecific.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands for transition metal catalysis.
• Material Science: Used in the preparation of specialty polymers and liquid crystals with tailored optical properties.
• Academic and R&D Laboratories: A standard reagent for methodological development in organic chemistry and stereochemistry studies.

Basic Information

Product Name	[R,(-)]-2-Bromobutane
CAS No.	5787-33-7
Molecular Formula	C4H9Br
Molecular Weight	137.02 g/mol
Synonyms	(R)-(-)-2-Bromobutane; (R)-2-Bromobutane; (-)-sec-Butyl bromide; (R)-sec-Butyl bromide; (2R)-2-Bromobutane; (R)-Butane, 2-bromo-; (R)-1-Bromo-1-methylpropane; D-(-)-2-Bromobutane
EINECS	227-313-8

Quality Control

Our [R,(-)]-2-Bromobutane is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by GC or HPLC, to ensure compliance with stringent specifications. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat, sparks, and open flame. Due to its highly volatile nature, keep container tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation [α]	-20.0° to -23.5° (c=1, neat)
Refractive Index (n20D)	1.436 - 1.438
Density (g/mL, 25°C)	1.258 - 1.268
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.