Description

n-tert-Butyltrimethylsilylamine is a specialized organosilicon amine derivative, valued for its role as a versatile silylating agent and protected amine synthon in advanced chemical synthesis. Its unique steric and electronic properties make it a critical reagent for introducing the tert-butyldimethylsilyl (TBDMS) protecting group, particularly for sensitive nitrogen functionalities. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key building block and protecting group reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Development: Employed in the creation of novel pesticides and herbicides where protected amine intermediates are required.
• Peptide Chemistry: Serves as a protecting agent for amino groups during solid-phase and solution-phase peptide synthesis.
• Material Science Precursor: Acts as a monomer or modifying agent in the synthesis of specialized silicon-containing polymers and coatings.
• Catalyst Ligand Modification: Utilized to synthesize novel nitrogen-based ligands for transition metal catalysts.
• Organic Synthesis Reagent: A fundamental tool for introducing the TBDMS group onto nitrogen atoms, offering stability under various reaction conditions.

Basic Information

Product Name	n-tert-Butyltrimethylsilylamine
CAS No.	5577-67-3
Molecular Formula	C7H19NSi
Molecular Weight	145.32 g/mol
Synonyms	N-(tert-Butyl)trimethylsilylamine; tert-Butyl(trimethylsilyl)amine; N-tert-Butyl-N-trimethylsilylamine; (tert-Butylamino)trimethylsilane; TBDMS-tert-butylamine; N-(tert-Butyl)-N-(trimethylsilyl)amine; 1,1-Dimethylethyl(trimethylsilyl)amine; N-t-Butyltrimethylsilylamine
EINECS	Contact for details

Quality Control

Our n-tert-Butyltrimethylsilylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for production, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.