Description

(15β)-20,21-Didehydro-16β-(Hydroxymethyl)-18,19-Secoyohimban-19-Oic Acid Methyl Ester is a high-purity, complex indole alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and reference standard for the study of bioactive molecules targeting the central nervous system. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly within the fields of neurology and psychiatry.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex indole alkaloids and potential drug candidates.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control in research and manufacturing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore modifications of the yohimbane skeleton for new biological activity.
• Biochemical Research: Investigated for its interaction with various neurotransmitter receptors and enzymes in preclinical studies.
• Process Development: Serves as a model compound for developing and scaling up chromatographic purification and crystallization processes for sensitive alkaloids.

Basic Information

Product Name	(15β)-20,21-Didehydro-16β-(Hydroxymethyl)-18,19-Secoyohimban-19-Oic Acid Methyl Ester
CAS No.	5552-25-0
Molecular Formula	C₂₂H₂₆N₂O₄
Molecular Weight	382.46 g/mol
Synonyms	Methyl (15β)-20,21-didehydro-16β-(hydroxymethyl)-18,19-secoyohimban-19-oate; 19-Nor-16β-(hydroxymethyl)-18,19-secoyohimban-19-oic acid methyl ester; 16β-Hydroxymethyl-18,19-seco-19-noryohimban-19-oic acid methyl ester; Secoyohimban derivative; Alstonia Scholaris Alkaloid Derivative; 18,19-Secoyohimban-19-oic acid, 20,21-didehydro-16β-(hydroxymethyl)-, methyl ester, (15β)-
EINECS	Contact for details

Quality Control

Every batch of (15β)-20,21-Didehydro-16β-(Hydroxymethyl)-18,19-Secoyohimban-19-Oic Acid Methyl Ester is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity research specifications, typically ≥95% by HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. Specifications can be customized to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.