Description

2-Bromobenzo[B]Thiophene is a high-purity brominated heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of pharmaceuticals, agrochemicals, and functional materials, enabling complex molecular architectures. It is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to introduce the benzo[b]thiophene scaffold into target molecules via cross-coupling reactions or further functionalization.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting central nervous system and oncological pathways.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene core.
• Material Science Research: Serves as a building block for organic semiconductors, conductive polymers, and nonlinear optical (NLO) materials due to its electron-rich structure.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Chemical Research & Development: A versatile reagent for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Dye and Pigment Intermediate: Used in the synthesis of specialized dyes and pigments where the benzo[b]thiophene unit modifies color and light-fastness properties.

Basic Information

Product Name	2-Bromobenzo[B]Thiophene
CAS No.	5394-13-8
Molecular Formula	C8H5BrS
Molecular Weight	213.09 g/mol
Synonyms	2-Bromobenzo[b]thiophene; 2-Bromobenzothiophene; Benzo[b]thiophene, 2-bromo-; 2-Bromo-1-benzothiophene; 2-Bromothianaphthene; NSC 404087; 2-BT
EINECS	226-394-9

Quality Control

Our 2-Bromobenzo[B]Thiophene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.