Description

Anhydro-(o-Carboxyphenyl)Phosphorochloridate is a specialized organophosphorus reagent characterized by its bifunctional reactive sites. This compound is critical for the synthesis of complex molecules where precise phosphorus-carbon bond formation is required. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs, prodrugs, and other bioactive molecules requiring phosphoramidate or phosphate ester linkages.
• Agrochemical Synthesis: Used in the production of advanced herbicides, insecticides, and plant growth regulators that incorporate phosphonate or phosphate functional groups.
• Ligand & Catalyst Preparation: Serves as a precursor for creating specialized phosphine ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Polymer Chemistry: Employed in the modification of polymers to introduce flame-retardant properties or to create functional monomers for specialty materials.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new methodologies in organophosphorus chemistry and medicinal chemistry.

Basic Information

Product Name	Anhydro-(o-Carboxyphenyl)Phosphorochloridate
CAS No.	5381-98-6
Molecular Formula	C7H4ClO4P
Molecular Weight	218.53 g/mol
Synonyms	2-Carboxyphenyl Phosphorochloridate Anhydride; Salicyloyl Phosphorochloridate; o-Carboxyphenyl Phosphorochloridate; Phosphorochloridic Acid, (2-Carboxyphenyl) Ester, Anhydride; 2-Hydroxybenzoyl Phosphorochloridate; Benzofuran-2(3H)-one, 3-chloro-3-oxido-; (2-Carboxyphenoxy)phosphonic Chloride
EINECS	Contact for details

Quality Control

Every batch of Anhydro-(o-Carboxyphenyl)Phosphorochloridate is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for high-purity synthetic intermediates. Comprehensive analytical testing, including HPLC, NMR, and titration methods, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in common organic solvents (e.g., THF, DCM, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.