Description

2-Chloro-3-Nitrothiophene is a versatile and high-value heterocyclic building block, essential for advanced organic synthesis. Its unique structure, featuring both chloro and nitro substituents on the thiophene ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and biological properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene scaffold.
• Material Science & Organic Electronics: Serves as a building block for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Dye & Pigment Manufacturing: Intermediate for producing specialized dyes and pigments with specific color fastness and light-absorption properties.
• Ligand & Catalyst Development: Useful in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Research & Development: A valuable reagent for academic and industrial research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	2-Chloro-3-Nitrothiophene
CAS No.	5330-98-3
Molecular Formula	C4H2ClNO2S
Molecular Weight	163.58 g/mol
Synonyms	3-Nitro-2-chlorothiophene; 2-Chloro-3-nitrothiophene; Thiophene, 2-chloro-3-nitro-; 2-Chloro-3-nitro-thiophene; NSC 403120; 2-Chloro-3-nitro-thiophene; 2-Chloro-3-nitrothiofene
EINECS	226-224-4

Quality Control

Every batch of our 2-Chloro-3-Nitrothiophene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles as determined by validated methods including HPLC, GC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.