Description

2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride is a high-purity, complex heterocyclic compound primarily utilized as a critical intermediate in advanced pharmaceutical synthesis. This compound matters for its role in constructing sophisticated molecular architectures, enabling the development of new therapeutic agents. It is specifically needed by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) and other bioactive molecules, where precise chemical building blocks are essential for innovation and process scale-up.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological pathways.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex polycyclic nitrogen-containing frameworks.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore and optimize biological activity.
• Process Chemistry Development: Utilized for route scouting and optimization in the pilot-scale production of advanced intermediates.

Basic Information

Product Name	2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride
CAS No.	5260-46-8
Molecular Formula	C14H20N2·2HCl
Molecular Weight	289.24 g/mol (Free base: 216.32 g/mol)
Synonyms	1,2,3,4,6,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline dihydrochloride; Pyrazinoisoquinoline dihydrochloride; 2H-Pyrazino[2,1-a]isoquinoline, 1,2,3,4,6,11b-hexahydro-, dihydrochloride; 5260-46-8 (CAS); UNII-9P4C9N8U4F; 9P4C9N8U4F; CHEMBL3183452; SCHEMBL15450497
EINECS	Contact for details

Quality Control

Our 2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and intermediate use. Certificates of Analysis (COA) documenting full specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.