Description

(+)-9-o-Desmethyl-α-Dihydrotetrabenazine is a high-purity, stereochemically defined derivative of tetrabenazine, a compound of significant interest in neurological research. This compound serves as a critical reference standard and advanced intermediate for the development of novel vesicular monoamine transporter 2 (VMAT2) inhibitors. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and contract research organizations (CROs) focused on neurodegenerative and movement disorders.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in the synthesis of VMAT2-targeting therapeutics.
• Neurological Research: Acts as a key intermediate or tool compound in preclinical studies investigating the pathophysiology and treatment of Huntington's disease, tardive dyskinesia, and Tourette syndrome.
• Metabolite Studies: Employed in the study of the metabolic pathways and pharmacokinetics of tetrabenazine and related analogs.
• Medicinal Chemistry: Serves as a sophisticated building block for the design and synthesis of next-generation VMAT2 modulators with improved selectivity and safety profiles.
• Process Chemistry Development: Used in the optimization and scaling of synthetic routes for complex active pharmaceutical ingredients (APIs) in the central nervous system (CNS) domain.

Basic Information

Product Name	(+)-9-o-Desmethyl-α-Dihydrotetrabenazine
CAS No.	5220-98-4
Molecular Formula	C18H25NO2
Molecular Weight	287.40 g/mol
Synonyms	(+)-9-Desmethoxy-α-dihydrotetrabenazine; (3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one; (+)-α-DHTBZ; Desmethyl Dihydrotetrabenazine; (+)-9-O-Desmethyl-α-DHTBZ; (3R,11bR)-9-O-Desmethyl-α-Dihydrotetrabenazine
EINECS	Contact for details

Quality Control

Our (+)-9-o-Desmethyl-α-Dihydrotetrabenazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.