Description

2-Methyl-D3-1,4-Naphthoquinone CAS NO 5172-16-7 is a deuterated analog of menadione, a synthetic form of Vitamin K3, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for advanced analytical and research applications requiring precise molecular tracking and quantification. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and manufacturers of high-purity reference standards engaged in metabolic studies, pharmacokinetics, and the development of novel therapeutic agents.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering internal standard for the accurate quantification of menadione and related Vitamin K compounds in complex biological matrices.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate the metabolic fate, biotransformation, and pharmacokinetic profiles of Vitamin K3 in vivo.
• Pharmaceutical Reference Standard: Employed as a certified reference material (CRM) for method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Research: Facilitates studies on the role of Vitamin K in blood coagulation, bone metabolism, and other physiological processes at a molecular level.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the high-purity labeled compound required for this gold-standard quantitative analytical technique.

Basic Information

Product Name	2-Methyl-D3-1,4-Naphthoquinone
CAS No.	5172-16-7
Molecular Formula	C11H5D3O2
Molecular Weight	175.20 g/mol
Synonyms	Menadione-d3; Vitamin K3-d3; 2-Methyl-1,4-naphthoquinone-d3; 2-Methyl-1,4-naphthalenedione-d3; 2-Methyl-3-deuterio-1,4-naphthoquinone; 2-Methylnaphthoquinone-d3; 2-Methyl-1,4-dihydro-1,4-dioxonaphthalene-d3; 3,5,8-Trideuterio-2-methyl-1,4-naphthoquinone
EINECS	Contact for details

Quality Control

Our 2-Methyl-D3-1,4-Naphthoquinone is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profile is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 99.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.