Description

1,2-Bis(Maleimido)Ethane is a high-purity, bifunctional cross-linking agent featuring two reactive maleimide groups. This compound matters for its ability to form stable covalent bonds with thiol groups under mild conditions, making it an essential tool for bioconjugation and polymer modification. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications ranging from antibody-drug conjugate (ADC) development to the synthesis of high-performance thermosetting resins.

Application

• Bioconjugation Linker: A key reagent for site-specific coupling of peptides, proteins, and antibodies with drugs, fluorophores, or other biomolecules in ADC and diagnostic probe development.
• Polymer Cross-linking Agent: Used to enhance the thermal stability, mechanical strength, and chemical resistance of polyimides, bismaleimide (BMI) resins, and other specialty polymers.
• Surface Functionalization: For modifying gold nanoparticles, quantum dots, or other material surfaces with thiol-containing ligands for sensor and device fabrication.
• Hydrogel Formation: Serves as a cross-linker in the synthesis of biocompatible hydrogels for drug delivery systems and tissue engineering scaffolds.
• Organic Synthesis Intermediate: Acts as a versatile building block for synthesizing more complex heterocyclic compounds and dendritic structures.

Basic Information

Product Name	1,2-Bis(Maleimido)Ethane
CAS No.	5132-30-9
Molecular Formula	C10H8N2O4
Molecular Weight	220.18 g/mol
Synonyms	N,N'-Ethylenebismaleimide; 1,1'-(Ethane-1,2-diyl)bis(1H-pyrrole-2,5-dione); Ethylene Bismaleimide; Bismaleimidoethane; 1,2-Bis(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethane; E-BMI; EDBM
EINECS	225-882-5

Quality Control

Our 1,2-Bis(Maleimido)Ethane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	195 - 205 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.