Description

4-Hydroxy-2-Thiophenecarboxylic Acid Methyl Ester is a versatile heterocyclic building block and key synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients and advanced materials. Pharmaceutical, agrochemical, and specialty chemical R&D teams need it for its reactive thiophene and ester functionalities, which enable diverse chemical transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides, leveraging the thiophene scaffold for bioactivity.
• Material Science Research: Serves as a monomer or building block for developing conductive polymers, organic semiconductors, and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal catalysis and organocatalysts due to its electron-donating and coordinating properties.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing specialized heterocyclic dyes and organic pigments.
• Academic & Industrial R&D: A valuable reagent for methodological chemistry research, including studies on heterocyclic chemistry and cross-coupling reactions.

Basic Information

Product Name	4-Hydroxy-2-Thiophenecarboxylic Acid Methyl Ester
CAS No.	5118-04-7
Molecular Formula	C6H6O3S
Molecular Weight	158.18 g/mol
Synonyms	Methyl 4-Hydroxythiophene-2-carboxylate; 4-Hydroxythiophene-2-carboxylic Acid Methyl Ester; 2-Thiophenecarboxylic acid, 4-hydroxy-, methyl ester; Methyl 4-hydroxy-2-thiophenecarboxylate; 4-Hydroxy-2-thiophenecarboxylic acid methyl ester; 4-Hydroxy-2-thiophene carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2-Thiophenecarboxylic Acid Methyl Ester is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.