Description

(4-(Hydroxymethyl)Phenyl)Diphenylphosphine Oxide is a versatile organophosphorus compound featuring a hydroxymethyl functional group, making it a valuable intermediate for advanced synthesis. Its unique structure provides a bifunctional handle for both phosphine oxide chemistry and further derivatization via the alcohol group. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors seeking to develop novel ligands, catalysts, or functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or acting as phosphine-based prodrugs.
• Ligand Precursor: Serves as a starting material for the preparation of chiral or bidentate phosphine ligands used in asymmetric catalysis and cross-coupling reactions.
• Polymer & Material Science: Incorporated into polymer backbones or as a surface modifier to impart flame-retardant properties, enhance thermal stability, or modify material surfaces.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, or plant growth regulators that utilize phosphine oxide chemistry.
• Coordination Chemistry: Used to synthesize metal-organic frameworks (MOFs) or complexes where the phosphine oxide acts as a coordinating ligand.
• Organic Synthesis Reagent: Employed in Horner-Wadsworth-Emmons (HWE) olefination reactions or as a stabilizing group in multi-step synthetic pathways.

Basic Information

Product Name	(4-(Hydroxymethyl)Phenyl)Diphenylphosphine Oxide
CAS No.	5068-20-2
Molecular Formula	C19H17O2P
Molecular Weight	308.31 g/mol
Synonyms	[(4-Hydroxymethyl)phenyl]diphenylphosphine oxide; 4-(Hydroxymethyl)benzenyldiphenylphosphine oxide; (4-Hydroxymethylphenyl)diphenylphosphine oxide; [4-(Hydroxymethyl)phenyl]diphenylphosphine oxide; Diphenyl[4-(hydroxymethyl)phenyl]phosphine oxide; p-(Hydroxymethyl)phenyldiphenylphosphine oxide; (p-Hydroxymethylphenyl)diphenylphosphine oxide
EINECS	Contact for details

Quality Control

Our (4-(Hydroxymethyl)Phenyl)Diphenylphosphine Oxide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and FT-IR to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay and impurity profiles. Our quality systems are designed to meet the stringent requirements of research and cGMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.