Description

n-Maleimidomethanol is a versatile heterobifunctional crosslinking agent featuring both a maleimide group and a primary hydroxyl group. This unique structure makes it a critical intermediate for the synthesis of advanced polymers, bioconjugates, and functional materials. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and specialty polymer industries who require precise and stable covalent linkages.

Application

• Bioconjugation and Protein Modification: The maleimide group selectively reacts with thiol groups (e.g., on cysteine residues) under mild conditions, enabling the site-specific attachment of drugs, labels, or polymers to antibodies, peptides, and other biomolecules.
• Polymer Synthesis and Functionalization: Serves as a key monomer or crosslinker for creating functional polymers, hydrogels, and dendrimers with tailored properties for drug delivery, coatings, and adhesives.
• Surface Immobilization Chemistry: Used to functionalize surfaces (e.g., gold, glass, polymers) with maleimide groups for the subsequent immobilization of thiol-containing ligands, enzymes, or DNA.
• Linker for Small Molecule Prodrugs: Enables the design of cleavable or stable linkers in antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Material Science Research: A valuable building block for developing novel smart materials, self-healing polymers, and responsive networks due to its dual reactivity.

Basic Information

Product Name	n-Maleimidomethanol
CAS No.	5063-96-7
Molecular Formula	C7H7NO3
Molecular Weight	153.14 g/mol
Synonyms	N-(Hydroxymethyl)maleimide; Maleimidomethanol; 1H-Pyrrole-2,5-dione, 1-(hydroxymethyl)-; Hydroxymethylmaleimide; N-Hydroxymethylmaleimide; 1-(Hydroxymethyl)-1H-pyrrole-2,5-dione; N-Maleimidomethanol
EINECS	225-759-8

Quality Control

Our n-Maleimidomethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at 2-8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetone; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.