Description

Trifluoroacetic Acid-D CAS NO 599-00-8 is the deuterated isotopologue of trifluoroacetic acid, where the acidic hydrogen is replaced by deuterium. This compound is a critical reagent in advanced analytical chemistry and pharmaceutical research, serving as a powerful solvent and derivatization agent. It is primarily utilized by researchers and manufacturers in the fields of nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and organic synthesis, particularly for mechanistic studies and the synthesis of deuterium-labeled compounds.

Application

• NMR Spectroscopy Solvent: As a deuterated solvent for proton NMR, providing a non-interfering signal for accurate structural analysis of organic molecules.
• Mass Spectrometry: Used as a volatile ion-pairing agent or mobile phase additive in LC-MS to improve ionization efficiency and peak shape.
• Deuterium Labeling Reagent: A key precursor for introducing deuterium atoms into target molecules for metabolic, pharmacokinetic, and mechanistic studies.
• Peptide Synthesis & Analysis: Employed as a cleavage agent and solvent in solid-phase peptide synthesis (SPPS) and for HPLC analysis of peptides and proteins.
• Catalyst & Reagent in Organic Synthesis: Acts as a strong acid catalyst or solvent in various organic transformations, including esterifications, hydrolyses, and rearrangements.
• Polymer & Material Science: Used in the production and processing of specialty polymers and as an etching agent in microfabrication processes.

Basic Information

Product Name	Trifluoroacetic Acid-D
CAS No.	599-00-8
Molecular Formula	C2D1F3O2
Molecular Weight	115.03 g/mol
Synonyms	Deuterated Trifluoroacetic Acid; Trifluoroacetic Acid-d1; Perfluoroacetic Acid-d; TFA-d; Trifluoroacetic-d Acid; 2,2,2-Trifluoroacetic-d Acid; Deutero-Trifluoroacetic Acid; CF3COOD
EINECS	209-958-6

Quality Control

Our Trifluoroacetic Acid-D is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D atom %), chemical purity, and impurity profiles. We adhere to relevant industry standards for high-purity reagents to support your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area, away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and strong acid/organic solvent nature, containers must be kept tightly sealed to prevent moisture absorption and evaporation.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Deuterium Content (NMR)	≥ 99.0 atom % D
Assay (Titration)	≥ 99.5%
Water Content (KF)	≤ 0.1%
NMR Solvent Suitability	Passes test

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.