Description

4,4'-Bis(Dimethylamino)-4''-(Methylamino)Trityl Alcohol is a specialized trityl-protected amine derivative, a key intermediate in advanced organic synthesis. Its core value lies in its role as a versatile protecting group for amines, particularly in the synthesis of complex molecules like oligonucleotides and peptides, where it offers selective deprotection advantages. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity building blocks for sensitive synthetic routes.

Application

• Oligonucleotide Synthesis: As a key protecting group reagent for exocyclic amino functions in nucleoside phosphoramidite chemistry.
• Peptide Synthesis: Used for the selective protection of amino acid side chains during solid-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Serves as a critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Fine Chemical Production: Employed in the synthesis of complex organic molecules, dyes, and functional materials requiring selective amine protection.
• Bioconjugation Chemistry: Useful in linker chemistry for attaching labels, drugs, or other functional groups to biomolecules.
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	4,4'-Bis(Dimethylamino)-4''-(Methylamino)Trityl Alcohol
CAS No.	561-41-1
Molecular Formula	C24H29N3O
Molecular Weight	375.51 g/mol
Synonyms	4,4',4''-Tris(dimethylamino)trityl alcohol; 4-(Dimethylamino)-4'-[4-(dimethylamino)phenyl](4-methylaminophenyl)methanol; MMTr-OH; Monomethoxytrityl alcohol; 4-Monomethoxytrityl alcohol; 4'-Methylamino-4,4''-bis(dimethylamino)trityl alcohol; 4-Monomethoxytrityl alcohol (MMTr-OH); [4-(Dimethylamino)phenyl][4-[4-(dimethylamino)phenyl](4-methylaminophenyl)methyl]phenyl]methanol
EINECS	Contact for details

Quality Control

Our 4,4'-Bis(Dimethylamino)-4''-(Methylamino)Trityl Alcohol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, IR), to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.