Description

4-Hydroxy-3-Methoxy-D3-Phenylethylene Glycol is a deuterium-labeled analog of the major norepinephrine metabolite, Vanillylmandelic Acid (VMA). This compound is of critical importance as an internal standard in quantitative analytical methods, particularly in mass spectrometry. It is primarily needed by research institutions, pharmaceutical companies, and clinical diagnostic laboratories for precise metabolic profiling, neurochemical research, and the development of assays for catecholamines and their metabolites.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of endogenous VMA and related metabolites in biological matrices like plasma, urine, and cerebrospinal fluid.
• Neurochemical Research: Used in studies investigating catecholamine metabolism, neurological disorders, and the biochemical pathways of neurotransmitters.
• Clinical Diagnostics: Enables the development and validation of high-precision diagnostic tests for conditions such as pheochromocytoma and neuroblastoma.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as a stable-isotope-labeled reference material to ensure method accuracy and precision in pharmacokinetic and metabolomic studies.
• Pharmaceutical Development: Applied in drug metabolism and pharmacokinetics (DMPK) studies for drugs affecting the sympathetic nervous system.
• Biomarker Validation: Critical for the validation of VMA as a clinical biomarker, improving the reliability of test results.

Basic Information

Product Name	4-Hydroxy-3-Methoxy-D3-Phenylethylene Glycol
CAS No.	534-82-7
Molecular Formula	C9H7D3O4
Molecular Weight	185.19 g/mol
Synonyms	3-Methoxy-4-hydroxyphenylethylene-D3-glycol; D3-VMA; Deuterated Vanillylmandelic Acid; 4-Hydroxy-3-methoxybenzeneethan-d3-1,2-diol; (2-Hydroxy-2-deuterio-1,1,2-trideuterioethyl)-4-hydroxy-3-methoxybenzene; HMPG-d3; MHPG-d3; Deuterium Labeled MHPG
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-Methoxy-D3-Phenylethylene Glycol is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles to ensure it meets the exacting standards required for analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.