Description

Frangulin A CAS NO 521-62-0 is a naturally occurring anthraquinone glycoside, specifically a rhamnoside of frangula-emodin, primarily extracted from the bark of *Rhamnus* species like alder buckthorn. This compound serves as a critical reference standard and active pharmaceutical ingredient (API) for quality control and research in the pharmaceutical and botanical extract industries. It is essential for manufacturers and research institutions focused on developing or standardizing laxative formulations, analytical methods, and studying plant-derived bioactive compounds.

Application

• Pharmaceutical Reference Standard: Primary use as a high-purity certified reference material (CRM) for the identification and quantification of frangulin A in herbal drug preparations and finished products.
• Botanical Extract Standardization: Key marker compound for the quality control and standardization of cascara sagrada, frangula (buckthorn), and other anthraquinone-containing herbal extracts.
• Active Pharmaceutical Ingredient (API): Used in the formulation of stimulant laxative medications, where precise dosing of the active anthraquinone component is required.
• Analytical Research & Method Development: Indispensable for developing and validating HPLC, UPLC, and TLC methods in analytical laboratories and quality control departments.
• Pharmacological & Biological Studies: Employed in research to investigate the pharmacological properties, metabolism, and potential biological activities of anthraquinone derivatives.
• Cosmeceutical Research: Investigated for potential applications in skincare products due to the bioactive properties of its aglycone, emodin.

Basic Information

Product Name	Frangulin A
CAS No.	521-62-0
Molecular Formula	C21H20O9
Molecular Weight	416.38 g/mol
Synonyms	Frangulin; Franguloside; 3-(6-Deoxy-α-L-mannopyranosyloxy)-1,8-dihydroxy-6-methyl-9,10-anthracenedione; Emodin 6-O-rhamnoside; 1,8-Dihydroxy-3-(α-L-rhamnopyranosyloxy)-6-methylanthraquinone; Alaterin; NSC 407303; Glucofrangulin A (aglycone reference)
EINECS	208-321-1

Quality Control

Our Frangulin A is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high purity for research and industrial applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with in-house specifications or tailored to meet the requirements of pharmacopoeial standards (e.g., USP, EP, BP) for use as a reference standard. COAs are available upon request and prior to shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.